About Pacritinib


Pacritinib (puh-CRIT-i-nib) is an oral, once daily, selective tyrosine kinase inhibitor (TKI) with activity against two important activating mutations: Janus Associated Kinase 2 (JAK2) and FMS-like tyrosine kinase 3 (FLT3). JAK2 is implicated in myeloproliferative neoplasms (MPN), leukemia and lymphoma, while FLT3 is a commonly mutated gene found in patients with acute myeloid leukemia (AML) and lymphoma. Pactrinib has demonstrated encouraging results in Phase 1 and 2 studies for patients with myelofibrosis and may offer an advantage over other JAK inhibitors through effective treatment of symptoms while having less treatment-emergent thrombocytopenia and anemia.

Development Status

PERSIST-1 is a multicenter, randomized, controlled Phase 3 trial comparing the efficacy and safety of pacritinib with that of best available therapy in patients with primary myelofibrosis.

Oral Pacritinib Versus Best Available Therapy to Treat Myelofibrosis Now enrolling.

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